Glycated hemoglobin screening identifies patients admitted for retreatment of tuberculosis at risk for diabetes in Tanzania.

نویسندگان

  • Margaretha L Sariko
  • Stellah G Mpagama
  • Jean Gratz
  • Riziki Kisonga
  • Queen Saidi
  • Gibson S Kibiki
  • Scott K Heysell
چکیده

INTRODUCTION World Health Organization recommendations of bidirectional screening for tuberculosis (TB) and diabetes have been met with varying levels of uptake by national TB programs in resource-limited settings. METHODOLOGY Kibong'oto Infectious Diseases Hospital (KIDH) is a referral hospital for TB from northern Tanzania, and the national referral hospital for multidrug-resistant (MDR)-TB. Glycated hemoglobin (HgbA1c) testing was done on patients admitted to KIDH for newly diagnosed TB, retreatment TB, and MDR-TB, to determine the point prevalence of diabetes (HgbA1c ≥ 6.5%) and prediabetes (HgbA1c 5.7%-6.4%). RESULTS Of 148 patients hospitalized at KIDH over a single week, 59 (38%) had no prior TB treatment, 22 (15%) were retreatment cases, and 69 (47%) had MDR-TB. Only 3 (2%) had a known history of diabetes. A total of 144 (97%) had successful screening, of which 110 (77%) had an HgbA1c ≤ 5.6%, 28 (19%) had ≥ 5.7 < 6.5, and 6 (4%) had ≥ 6.5. Comparing subjects with prediabetes or diabetes to those with normal A1c levels, retreatment patients were significantly more likely to have a A1c ≥ 5.7% (odds ratio: 3.2, 95% CI: 1.2-9.0; p = 0.02) compared to those without prior TB treatment. No retreatment case was a known diabetic, thus the number needed to screen to diagnose one new case of diabetes among retreatment cases was 11. CONCLUSIONS Diabetes prevalence by HgbA1c was less common than expected, but higher HgA1c values were significantly more frequent among retreatment cases, allowing for a rational, resource-conscious screening approach.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Moderating Role of Alexithymia in Relationship Between Perceived Social Support, Diabetes-Related Quality of Life, and Glycated Hemoglobin in Patients With Type 2 Diabetes

Background: Diabetes is a complex and chronic disease, i.e. associated with patients’ lifestyle and affects their quality of life. The present study examined the role of alexithymia on the relationship between social support, health-related quality of life, and glycated hemoglobin in patients with type 2 diabetes.  Methods: This was an analytical cross-sectional study. The study participants c...

متن کامل

Correlation between Glycated Hemoglobin, Serum Glucose and Serum Lipid Levels in Type 2 Diabetes

Abstract Objective: Diabetes mellitus is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which is induced by hyperlipidemia. Impaired lipid metabolism resulting from uncontrolled hyperglycemia has been implicated in cardiovascular complications in diabetic patients. Also, glycated hemoglobin (HbA1c) has been rega...

متن کامل

Trend of Changes in Blood Sugar and Glycated Hemoglobin in Electronic Health Records, Sari, Iran 2012- 2018

Background and purpose: High prevalence of Type 2 Diabetes Mellitus (T2DM) and its demand for regular care have resulted in a massive amount of electronic health records (EHRs). Hemoglobin A1c (HbA1c) and Fasting Blood Sugar (FBS) levels are two widely-used diagnostic measures for evaluation of diabetes care. This study aimed at assessing Family Medicine Plan (FMP) and exploring the trend of ch...

متن کامل

بررسی عوامل خطر همراه با نفروپاتی در بیماران دیابتی نوع II ؛ براساس آزمون مدل زیستی، روانی- اجتماعی

Introduction & Objective: The study of biopsychosocial factors influencing nephropathy as a most serious complication of type II diabetes is important. This study aimed to investigate risk factors accompanied with nephropathy in patients with type II diabetes based on the biopsychosocial model. Materials & Methods: In a cross-sectional descriptive study, 295 patients with type II diabetes we...

متن کامل

رابطه حمایت اجتماعی ادراک شده و هموگلوبین گلیکوزیله در مبتلایان به دیابت نوع دو: نقش تعدیل‌کننده الکسیتایمیا

Background: One of the important goals in control diabetes to maintain normal levels of glycated hemoglobin, but different social and psychological factors such as social support and alexithymia play role on process of this control. The purpose of present study was to examine the role of alexithymia on the association of social support and glycated hemoglobin in patients with type 2 diabetes. M...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of infection in developing countries

دوره 10 4  شماره 

صفحات  -

تاریخ انتشار 2016